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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 714-728 doi: 10.1007/s11684-022-0959-5

Abstract: Mechanistically, FRMD6 interacts and colocalizes with mTOR and S6K, which are the key molecules of themTOR signaling pathway.Furthermore, knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6Altogether, our results show that FRMD6 contributes to lung cancer progression by activating the mTORsignaling pathway.

Keywords： FRMD6     lung cancer     mTOR pathway    

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Prohibitin regulates mTOR pathway via interaction with FKBP8

Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 448-459 doi: 10.1007/s11684-020-0805-6

Abstract: The PI3K–Akt–mTOR axis is one of the most frequently modified signaling pathways whose activation sustainsFK506 binding protein 8 (FKBP8) is an intrinsic inhibitor of mTOR kinase that also exerts an anti-apoptoticFurthermore, the downregulation of PHB1 inhibited the proliferation of ovarian cancer cells and the mTORsignaling pathway, whereas the FKBP8 level in the mitochondria was substantially reduced.Moreover, concomitant with these changes, the interaction between FKBP8 and mTOR substantially increased

Keywords： prohibitin 1     FKBP8     mTOR     cell proliferation     cancer    

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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: The mammalian target of rapamycin (mTOR) critically regulates several essential biological functions,cell growth, metabolism, survival, and immune response by forming two important complexes, namely, mTORcomplex 1 (mTORC1) and complex 2 (mTORC2). mTOR signaling is often dysregulated in cancers and has beenGreat efforts have been made to develop efficacious mTOR inhibitors, particularly mTOR kinase inhibitorstherapeutic strategies with mTOR inhibitors against cancer.

Keywords： mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

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Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTORpathway

Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 697-706 doi: 10.1007/s11684-018-0655-7

Abstract: Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway.suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTORpathway.

Keywords： resveratrol     reactive oxygen species     AMPK     mTOR     autophagy    

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Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1637-9

Abstract:

● Converting xylose to caproate under a low temperature of 20 °C by MCF was verified.

Keywords： Xylose fermentation     Caproate     Low temperature     Bifidobacterium     FAB pathway     RBO pathway    

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Diet Enhances Muscle Weight and Postprandial Protein Synthesis of Skeletal Muscle by Promoting the mTORPathway in Adult Rats

Bo Zhang, Licui Chu, Hong Liu, Chunyuan Xie, Shiyan Qiao, Xiangfang Zeng

Engineering 2017, Volume 3, Issue 5,   Pages 760-765 doi: 10.1016/J.ENG.2017.03.008

Abstract: were harvested and weighed, and the fractional synthesis rate (FSR) and mammalian target of rapamycin (mTORsupplementation moderately improves body weight gain and increases muscle protein synthesis through mTOR

Keywords： Low-protein diet     Leucine     Growth performance     Muscle weight     Protein synthesis     Adult rats    

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Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 157-162 doi: 10.1007/s11684-011-0128-8

Abstract: At present, clinical pathway has become one of the most important health care reform measures in manyIn this study, the authors introduced basic concepts and explored the application of the clinical pathwaySuch concepts provide examples and experiences, on which the application of clinical pathway in Chinese

Keywords： evidence-based medicine     clinical pathway     methodology     concept     technical difficulty    

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Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 403-409 doi: 10.1007/s11684-017-0522-y

Abstract:

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation

Keywords： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle    

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Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 637-650 doi: 10.1007/s11684-021-0864-3

Abstract: Further evidence suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway

Keywords： apigenin     aminoglycosides     ototoxicity     oxidative stress     Nrf2 signaling pathway    

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Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus

Xiaoxuan Zhu,Xinyi Zeng,Chao Sun,Shilin Chen

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 285-293 doi: 10.1007/s11684-014-0350-2

Abstract: Here we review the recent advances in the biosynthetic pathway of terpenoid indole alkaloids (TIAs) inSecologanin is derived from terpenoid (isoprenoid) biosynthetic pathway, while tryptamine is derivedfrom indole biosynthetic pathway.Although many genes and corresponding enzymes have been characterized in this pathway, our knowledgeon the whole TIA biosynthetic pathway still remains largely unknown up to date.

Keywords： Catharanthus roseus     terpenoidindole alkaloids     biosynthetic pathway     vinblastine     vincristine    

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Autophagy and the nutritional signaling pathway

Long HE,Shabnam ESLAMFAM,Xi MA,Defa LI

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 3,   Pages 222-230 doi: 10.15302/J-FASE-2016106

Abstract: During their growth and development, animals adapt to tremendous changes in order to survive. These include responses to both environmental and physiological changes and autophagy is one of most important adaptive and regulatory mechanisms. Autophagy is defined as an autolytic process to clear damaged cellular organelles and recycle the nutrients via lysosomic degradation. The process of autophagy responds to special conditions such as nutrient withdrawal. Once autophagy is induced, phagophores form and then elongate and curve to form autophagosomes. Autophagosomes then engulf cargo, fuse with endosomes, and finally fuse with lysosomes for maturation. During the initiation process, the ATG1/ULK1 (unc-51-like kinase 1) and VPS34 (which encodes a class III phosphatidylinositol (PtdIns) 3-kinase) complexes are critical in recruitment and assembly of other complexes required for autophagy. The process of autophagy is regulated by autophagy related genes (ATGs). Amino acid and energy starvation mediate autophagy by activating mTORC1 (mammalian target of rapamycin) and AMP-activated protein kinase (AMPK). AMPK is the energy status sensor, the core nutrient signaling component and the metabolic kinase of cells. This review mainly focuses on the mechanism of autophagy regulated by nutrient signaling especially for the two important complexes, ULK1 and VPS34.

Keywords： Autophagy     ULK1 complex     VPS34 complex     AMPK     mTOR     nutrient signaling    

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Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 68-78 doi: 10.1007/s11684-014-0308-4

Abstract: The planar cell polarity (PCP) pathway controls the process of convergent extension (CE) during gastrulationThis review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs

Keywords： planar cell polarity     neural tube defects     rare mutations    

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NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 263-274 doi: 10.1007/s11684-022-0935-0

Abstract: of calcium ions (Ca2+) and the expression of key genes involved in the calcium signaling pathway

Keywords： melanoma     neuropilin and tolloid-like 2     Ca2+/CaMKII signaling pathway    

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Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract: an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling pathway

Keywords： XKQ     type 2 diabetes mellitus     KKAy mice     PI3K/Akt pathway     diabetic liver disease    

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Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 216-228 doi: 10.1007/s11684-008-0042-x

Abstract: -catenin signaling pathway has been identified as a key cellular pathway in embryogenesis and diseaseobserved and their exact functions approached, thus ensuring the most complicated understanding of this pathwayIn hepatocellular carcinoma (HCC), with a deeply understanding of this pathway, more and more genes which-catenin signaling pathway has recently been identified and their exact roles in HCC pursued.In this review, we will focus on a mostly updated understanding of this pathway and its observed role

Keywords： interacting     complicated understanding     embryogenesis     activation     organism development    

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Title Author Date Type Operation

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Journal Article

Prohibitin regulates mTOR pathway via interaction with FKBP8

Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTORpathway

Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia

Journal Article

Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation

Journal Article

Diet Enhances Muscle Weight and Postprandial Protein Synthesis of Skeletal Muscle by Promoting the mTORPathway in Adult Rats

Bo Zhang, Licui Chu, Hong Liu, Chunyuan Xie, Shiyan Qiao, Xiangfang Zeng

Journal Article

Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

Journal Article

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Journal Article

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Journal Article

Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus

Xiaoxuan Zhu,Xinyi Zeng,Chao Sun,Shilin Chen

Journal Article

Autophagy and the nutritional signaling pathway

Long HE,Shabnam ESLAMFAM,Xi MA,Defa LI

Journal Article

Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Journal Article

NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Journal Article

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Journal Article

Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Journal Article